Methyl 5-(trifluoromethyl)nicotinate
Methyl 5-(trifluoromethyl)nicotinate
CAS: 124236-38-0
Molecular Formula: C8H6F3NO2
Methyl 5-(trifluoromethyl)nicotinate - Names and Identifiers
Methyl 5-(trifluoromethyl)nicotinate - Physico-chemical Properties
| Molecular Formula | C8H6F3NO2 |
| Molar Mass | 205.13 |
| Density | 1.331±0.06 g/cm3(Predicted) |
| Boling Point | 217.1±40.0 °C(Predicted) |
| pKa | 0.77±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD11100701 |
Methyl 5-(trifluoromethyl)nicotinate - Introduction
Methyl 5-trifluoromethylnicotinate (also known as TFMA) is an organic compound with the chemical formula C8H5F3O3. It is a colorless liquid with several specific properties.
Nature:
1. 5-Trifluoromethyl nicotinic acid methyl ester has high thermal stability and is not easy to decompose or fail under high temperature conditions.
2. It is a polar solvent, soluble in many organic solvents, such as ethanol, dimethylformamide, etc.
3. TFMA has strong acidity and can be used as acid catalyst.
Use:
1. 5-Trifluoromethyl nicotinic acid methyl ester can be used as a catalyst in organic synthesis, especially in acid-catalyzed reactions.
2. It can also be used as a reagent in organic synthesis, such as nucleophilic reagents, acyl reagents, etc.
3. TFMA has certain applications in the field of medicine, such as for the synthesis of anticancer drugs.
Preparation Method:
Methyl 5-trifluoromethylnicotinate can be obtained by reacting methyl nicotinate (Methyl nicotinate) with trifluoromethanesulfonate (Trifluoromethanesulfonic anhydride). The reaction is usually carried out under the protection of an inert gas. A suitable solvent can be selected and the reaction is carried out at a suitable temperature.
Safety Information:
5-trifluoromethylnicotinic acid methyl ester is a chemical, the use should pay attention to the following safety matters:
1. contact with skin, eyes or inhalation of its vapor, may cause irritation and corrosion, should wear appropriate personal protective equipment, such as gloves, goggles and protective mask, to ensure good ventilation.
2. avoid contact with combustible materials, storage should be away from fire and high temperature.
3. Do not discharge it into the environment, and dispose of the waste in accordance with relevant regulations.
4. In case of accident or discomfort, seek medical attention immediately and show the chemical label to the doctor.
Nature:
1. 5-Trifluoromethyl nicotinic acid methyl ester has high thermal stability and is not easy to decompose or fail under high temperature conditions.
2. It is a polar solvent, soluble in many organic solvents, such as ethanol, dimethylformamide, etc.
3. TFMA has strong acidity and can be used as acid catalyst.
Use:
1. 5-Trifluoromethyl nicotinic acid methyl ester can be used as a catalyst in organic synthesis, especially in acid-catalyzed reactions.
2. It can also be used as a reagent in organic synthesis, such as nucleophilic reagents, acyl reagents, etc.
3. TFMA has certain applications in the field of medicine, such as for the synthesis of anticancer drugs.
Preparation Method:
Methyl 5-trifluoromethylnicotinate can be obtained by reacting methyl nicotinate (Methyl nicotinate) with trifluoromethanesulfonate (Trifluoromethanesulfonic anhydride). The reaction is usually carried out under the protection of an inert gas. A suitable solvent can be selected and the reaction is carried out at a suitable temperature.
Safety Information:
5-trifluoromethylnicotinic acid methyl ester is a chemical, the use should pay attention to the following safety matters:
1. contact with skin, eyes or inhalation of its vapor, may cause irritation and corrosion, should wear appropriate personal protective equipment, such as gloves, goggles and protective mask, to ensure good ventilation.
2. avoid contact with combustible materials, storage should be away from fire and high temperature.
3. Do not discharge it into the environment, and dispose of the waste in accordance with relevant regulations.
4. In case of accident or discomfort, seek medical attention immediately and show the chemical label to the doctor.
Last Update：2024-04-09 02:00:41
